Rac2 in the zebrafish (Danio rerio) with a focus on neutrophils
نویسندگان
چکیده
iv CHAPTER 1. General Introduction 1 CHAPTER 2. Literature Review 5 CHAPTER 3. Rac2 expression in the zebrafish (Danio rerio) 25 CHAPTER 4. Rac2 function in the adult zebrafish neutrophil 45 CHAPTER 5. The effect of Rac2 inhibition and gene knockdown during infectious disease on the mortality of zebrafish (Danio rerio) embryos infected via immersion 61 CHAPTER 6. General Conclusions 75
منابع مشابه
Evaluation of of the performance of the zebrafish (Danio rerio) model in nanotoxicology studies with emphasis on embryo pathology
The present study was conducted to evaluate the performance of zebrafish (Danio rerio) as a model in embryo and fetal pathology in nanotoxicology studies. Examination of the sources showed that it is possible to completely inhibit hatching and fetal death when exposed to nanoparticles, because nanoparticles interact with hatching enzymes. Zebrafish embryo developmental abnormalities have been s...
متن کاملHistopathological Changes of Zebrafish (Danio rerio) Ovaries Exposed to Sub-lethal Concentrations of Methyl Paraben
Paraben compounds are used widely as preservatives to inhibit microbial growth and extend used in pharmaceuticals, hygienic, cosmetics, care products. They pose the potential for reproductive toxicity for users. This paper provides an overview of the applications of histopathological biomarkers in reproductive toxicity in zebrafish caused by methylparaben. The present study investigated the cha...
متن کاملInvestigation of Toxicological Effects of di-2-ethylhexyl with Fish Embryo Test (FET) in Zebrafish (Danio rerio)
Di(2-ethylhexyl)phthalate (DEHP) is a plasticizer in a variety of consumer products. Given the adverse toxicity effects of DEHP on living organisms, its high consumption and dispersal has been caused a serious concern. . Nowedays, the Fish Embryo Test (FET) method is widely used among the conventional methods of toxicology .The aim of the this study was to determine the acute toxicity of Di(2-e...
متن کاملA review of the performance of zebrafish (Danio rerio) as a model organism in nanotoxicological research and its differences with other animal models
Today, nanotechnology is recognized as one of the leading sciences in the world, which manipulates atoms and molecules in order to produce valuable products. Extensive use of nanomaterials in various industrial sectors has increased the possibility of their diffusion in water bodies and the environment. Therefore, the study of toxicity of these substances is considered as one of the research ne...
متن کاملEffect of Cadmium Chloride on Maturity of Female Zebrafish (Danio rerio) using Vitellogenin Biomarker and Ovary Histopathology
This study aimed to investigatethe changes in Gonad Somatic Index (GSI), vitellogenin induction and ovarian histopathology in zebrafish (Danio rerio) adult female, as an ecological model in toxicology, after exposure to 0.002, 0.02, 0.2, 2 and 20 µg/L cadmium chloride for 21 days under sub-lethal condition. The results showed that 0.002 to 20 µg/L cadmium chloride had no significant effect on t...
متن کامل